Biological evaluation of 2-arylidene-4-(4- methoxy/phenoxy-phenyl)but-3-en-4- olides
نویسنده
چکیده
A series of nine 2-arylidene-4-(4methoxy/phenoxy-phenyl)but-3-en-4-olides (I-IX) were screened against Pheretima posthuma earthworm species to assess the anthelmintic activity of the synthetic derivatives. The in vitro effects of compounds were evaluated at a concentration of 2mg/mL and time taken by the derivatives to paralyze and subsequently kill the worms was recorded. Synthetic butenolide derivatives exhibited moderate to good anthelmintic activity but among all tested compounds, compound VII was found to be the most potent against Pheretima posthuma. The anthelmintic activity of compound VII could be comparable to that of the standard drug.
منابع مشابه
Anthelmintic activity evaluation of 2-arylidene-4-(biphenyl-4-yl) but-3-en-4-olides
ARTICLE INFO Received: 18/10/2015 Revised: 31/10/2015 Accepted: 11/11/2015 Available Online: 24/11/2015
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